In comparison, despite the absence of mortality after subcutaneous inoculation, WNV-E218A showed enhanced peripheral infection in Ifit1−/− mice and accumulated in the serum and spleen to comparable levels observed in wild type mice infected with WNV-WT (P<0.05, comparison of WNV-E218A between wild type and Ifit1−/− mice; Figure 1B and C). The gene discussed is IFIT1; the disease is infection.