At 48 and 72 hours after infection, Ifit1−/− CN infected with WNV-WT showed lower viability compared to wild type CN (48 hours: 83.4% viable wild type cells versus 73.3% viable Ifit1−/− cells, P<0.0001; and 72 hours: 58.8% viable wild type cells versus 45.2% viable Ifit1−/− cells, P<0.0001) (Figure 6A); this effect, however, was not associated with differences in viral replication between wild type and Ifit1−/− CN (see Figure 4C). Here, IFIT1 is linked to infection.