Compared with vehicle controls, treatment of NPC cells with the TNFR ligand TNF-α (50 or 100 ng/ml) or the IL-1R ligand IL-1α (10 ng/ml) for 30 min had little effect on Cdc42 activation (Figure S1A) and on actin remodeling (Figure S1B). The gene discussed is IL1R1; the disease is nasopharyngeal carcinoma.