To reinforce the functional role of FGD4, we re-introduced FGD4 expression by ectopically expressing FGD4 (Myc-FGD4) in FGD4-depleted NPC cells that co-expressed LMP1, and then assessed the activation of Cdc42 by LMP1. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.