Following axonal infection of TGEs with HSV-1 IE4proEGFP in the presence of CHX, IE gene expression was significantly increased by infection of the GC with HSV-1 KOS RP5R, whereas the addition of RP5 did not lead to a significant transcriptional transactivation of the reporter gene at 6 hpi (Figure 6A). The gene discussed is SREBF2-AS1; the disease is infection.