CYBA and familial pancreatic carcinoma: Western blot analysis of the K-rasG12V stably transformed cells and two naturally occurring pancreatic cancer cell lines (AsPC1 and Panc-1) showed that the protein level of p22phox, an essential component of the NOX enzyme complex, was substantially higher in pancreatic cancer cells than in non-malignant HPDE cells (Figure 7C).