To test the effect of NOX suppression on tumor growth in vivo, we subcutaneously inoculated the Panc-1 cells bearing p22phox-shRNA into the left flank of athymic nude mice (n = 7) and Panc-1 cells bearing control shRNA into the right flank of the same 7 mice (5×106 cells/injection site). The gene discussed is CYBA; the disease is neoplasm.