Furthermore, it has been shown that cytosolic cytochrome c is sufficient to induce apoptosis in various human neoplastic cell lines: neuroblastoma (SH-SY5Y), glioblastoma (MGR3, MGR1, D54MG, D247MG, and H392), and medulloblastoma (UW228, D341MED, and MCD1). This evidence concerns the gene CYCS and neuroblastoma.