Clark level, location of the primary melanoma, age, and sex are less important predictors.3,10 The prognostic significance of primary melanoma characteristics cannot be identified for patients with nodal metastasis undergoing TLND.5 For this group of patients, a recent study showed that a preoperatively elevated S-100B tumor marker had a negative prognostic value.11 The gene discussed is S100B; the disease is melanoma.