Had RBP4 levels been associated with measures of glucose homeostasis as in certain prior studies, a u-shaped association with coronary atherosclerosis might be supported given the heightened CVD death not only with hyperglycemia, but also potentially with hypoglycemia, as suggested by the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial results [35]. Here, RBP4 is linked to Hyperglycemia.