Also, VitD modulates lymphocytic cytokine production [33], potentially affecting growth and proliferation of vascular smooth muscle cells and cardiomyocytes [34], stimulating vascular tissue anticoagulant activity [35], and suppressing renin gene expression [36], which could lead to the clinical manifestations of hypertension, coronary artery disease, and congestive heart failure. The gene discussed is REN; the disease is congestive heart failure.