This finding is supported by studies in rodents showing that a high fat diet for 5–20 weeks increased PGC1α and the activity and expression of proteins involved in skeletal muscle oxidative capacity [9], [13], [14], [15], [28], [29] in concert with induction of glucose intolerance and/or insulin resistance [13], [15]. The gene discussed is PPARGC1A; the disease is Insulin resistance.