AR and menopausal or post-menopausal disease: These effects could not be blocked by the androgen receptor antagonist flutamide (Figure 5), but were in contrast blocked by co-exposure with ICI (Figure 4) In addition, two synthetic progestins, norethindrone and levonorgestrel, commonly used in oral contraception and post-menopausal disorders, induced GFP expression in a concentration-dependent manner (Figure 3d), while progesterone was inactive.