Accordingly, in the experimental conditions that we have been consistently using with different cell types [17]–[19], which reproduce a moderate or severe hyperbilirubinemia [UCB to human serum albumin (HSA) molar ratios of 0.5 and 1.0, respectively], toxicity is observed and oxidative stress appears as a relevant event [20]–[22]. This evidence concerns the gene ALB and Hyperbilirubinemia.