It seems there is a synergistic loop between HER2 and HSF1, and slight changes in HSF1 level (regulated by rs4919510:C>G in miR-608) might be amplified by the loop, resulting in more significant alterations in HSF1/HSPs level and consequently facilitating pathological outcomes such as HER2+ breast cancer transformation and proliferation (illustrated in Figure 1D). This evidence concerns the gene ERBB2 and breast cancer.