In the sub-analysis according to the IHC-based breast cancer subtypes (Table 2), although we did not observe any significant relationship between rs4919510:C>G and luminal-like or triple-negative subtype, a remarkable increase in risk of HER2+ subtype (n = 133) was found in women carrying variant genotypes (CG/GG) in a dose-effect manner (Bonferroni corrected P of 3.6×10−3 for trend, and of 9.3×10−4 for heterogeneity). This evidence concerns the gene ERBB2 and breast cancer.