rs4919510:C>G was independently related to HER2+ breast cancer risk in the dominant model (OR = 2.10, 95% CI, 1.15–3.82), recessive model (OR = 1.97, 95% CI, 1.34−2.90), as well as additive model (CG vs. CC, OR = 1.63 with 95% CI of 0.87−3.08; GG vs. CC, OR = 2.87 with 95% CI of 1.52−5.42; overall P = 0.001). Here, ERBB2 is linked to breast carcinoma.