DRB1*16∶02-DQB1*05∶02 was significantly associated with ILD positive RA (n = 4 [1.6%] in ILD positive RA vs. n = 1 [0.2%] in ILD negative RA, P = 0.0257, OR 10.09), but DRB1*14∶54-DQB1*05∶02 was not (n = 2 [0.8%] in ILD positive RA vs. n = 13 [2%] in ILD negative RA, P = 0.2544, OR 0.38). This evidence concerns the gene HLA-DRB1 and interstitial lung disease.