TTR and polyneuropathy: Tafamidis, a novel specific inhibitor of TTR tetramer dissociation has been evaluated in a prospective placebo-controlled phase II/III clinical trial in FAP patients and found to reduce the progression of polyneuropathy in the majority of patients (http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002294/human_med_001498.jsp&mid=WC0b01ac058001d124).