Even if to date and to our knowledge, the role of fat tissue has not been widely investigated in ankylosing spondylitis (AS), several indirect results suggest a possible link between the AS-related inflammation and fat tissue excess: (a) weight loss and subsequent lower BMI are linked to a high RA activity [5]; and (b) a significant increase in body weight and fat mass has been observed in AS patients receiving anti-tumor necrosis factor (TNF)-α treatment [6]. The gene discussed is TNF; the disease is rheumatoid arthritis.