Apart from the possibility of a potential genetic tendency there are some well known carcinogens in head and neck squamous cell carcinoma (HNSCC) such as tobacco, alcohol, viruses like the human papilloma virus (HPV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), as well as immunosuppression, polymorphism of interleukin 6 (IL6) and tumor necrosis factor (TNF) [7] and inherited syndromes, e.g. Fanconi anemia, Aplastic anemia [8] that all may play a role in the carcinogenesis process. This evidence concerns the gene TNF and aplastic anemia.