The cell line data presented here may offer an explanation for this in that cell lines with Syndecan predominant HSPG pattern (or perhaps, as described for survival in other cancers, cells that have lost CD44v3 expression) become more platinum resistant when chronically exposed to DcR3 while the cell line with CD44v3 as a more dominant HSPG become more platinum sensitive. This evidence concerns the gene SDC2 and cancer.