DcR3 also demonstrates diverse effects on cells of monocyte/macrophage lineage were it has been shown to increase monocyte adhesion [13,17], skew macrophage to an M2 tumor associated phenotype, negatively alter their antigen presenting function, and to directly result in the apoptosis of dendritic cells [12,18-22]. Here, TNFRSF6B is linked to neoplasm.