A basic calculation of incidence rates across the five-year age bands showed that ER-PR- breast cancer rates were stable across all age bands above age 50 (for ≤49 years: 16.9, 50 to 54 years: 34.6, 55 to 59 years: 36.9, 60 to 64 years: 38.4, ≥65 years: 29.1 per 100,000 person years), whereas ER+PR+ disease, rates increased steadily with increasing age albeit at a slower rate after 50 years (for ≤49 years: 44.5, 50 to 54 years: 111.2, 55 to 59 years: 125.4, 60 to 64 years: 142.6, ≥65 years: 127.9 per 100,000 person years). Here, ESR1 is linked to breast cancer.