In addition, an analysis within the Women's Health Initiative cohort [39] showed a moderate increase in risk of triple-negative (ER-/PR-/HER2-) breast tumors among postmenopausal women who had more elevated BMI (HR = 1.35 (95%CI = 0.92 to 1.99) for the top versus bottom quartiles of BMI). This evidence concerns the gene PGR and breast neoplasm.