Given the biologically distinct roles of both BDNF forms, with proBDNF linked to apoptotic pathways and long-term depression and mature BDNF linked to enhanced plasticity (Lu et al. 2005), the effects of duloxetine and DOV 216,303 on proteolytic processing of proBDNF are an interesting issue that may warrant future investigation. The gene discussed is BDNF; the disease is depressive symptom measurement.