It is noteworthy though that the present study, despite the relatively small sample size and its diagnostic heterogeneity, could provide such distinct findings on grey matter volumes in association with the two at-risk SNPs of DTNBP1. Given the phenotypic and genetic overlap of schizophrenia with bipolar disorder [40], the present results support existing evidence that genetic variation of DTNBP1 may not only be a risk factor for schizophrenia, but also play a role in a broader context of psychiatric disorders including affective psychoses. Here, DTNBP1 is linked to bipolar disorder.