Moreover, cognitive impairment and abnormal executive functioning in schizophrenia and bipolar disorder have been reported in association with DTNBP1 risk genotypes [8, 15], and deviating brain activation in prefrontal, temporal and parietal areas during cognitive and emotional tasks has been described in healthy carriers of DTNBP1 risk alleles [33, 41, 42, 72, 84]. Here, DTNBP1 is linked to bipolar disorder.