An expression profile of the three DLC1 isoforms - variants 1, 2, and 3 - in normal and malignant hepatic tissue, showed that only variant 1 was silenced by promoter methylation; variants 1 and 2 (but not variant 3) localize at focal adhesions and suppress stress fiber formation and in vitro HCC cell proliferation (69). The gene discussed is DLC1; the disease is hepatocellular carcinoma.