Deletions at this location, unbalanced translocations with breakpoints near the SMAD5 locus, recurrent formation of isochromosome 5q resulting in selective loss of 5p and gain of 5q, and intrachromosomal amplification of SMAD5 at FRA5C have been detected; all point to this locus as relevant in the development of HCC. Here, SMAD5 is linked to hepatocellular carcinoma.