Regardless of these issues, targeting GluN2B-PSD95 signaling to neurotoxic pathways offers genuine translational potential because it has been recently shown that stroke-induced damage and neurological deficits can be prevented in nonhuman primates by the administration of TAT-NR2Bc as late as 3 hr after stroke onset (Cook et al., 2012). This evidence concerns the gene DLG4 and Stroke.