Additionally, the multivariate analysis identified CLIC1 expression (HR, 4.66; 95% CI, 2.31–10.29; P=0.01) and WHO grade (HR, 6.97; 95% CI, 2.12–12.46; P=0.008) as significant prognostic factors for glioma (Table 3). This evidence concerns the gene CLIC1 and central nervous system cancer.