INS and diabetes mellitus: We believe that the less we use of sulphonylureas, the less will be the relevance of this “secondary failure.” Given that β-cell dysfunction is prominent at the time of diagnosis of diabetes and given the rate of decline of β-cell function with time [10, 13], it does not seem necessary to trigger the production of endogenous insulin by a dysfunctional β-cell, when the plasma levels of insulin itself are already, in almost all instances, elevated.