NR0B2 and obesity due to melanocortin 4 receptor deficiency: The previously reported [111] c.512G>C [p.G171A] common polymorphism was identified; however, the prevalence of functional SHP variants associated with obesity was considerably lower among Danish subjects (1 out of 750 obese, none of control subjects), compared to the prevalence observed in Japan by Nishigori et al. [111].