MODY is a monogenic form of early-onset diabetes mellitus (defective insulin secretion with normal body weight), and SHP is deemed as a plausible candidate MODY gene; this is because SHP is able to inhibit the transcriptional activity of the hepatocyte nuclear factor-4α (HFN-4α), a key member of the MODY regulatory network. This evidence concerns the gene NR0B2 and MODY.