RASSF1 and hepatocellular carcinoma: Reexpression of RASSF1A using 5-aza-2′-deoxycytidine or reintroduction of RASSF1A into the hepatocellular carcinoma cell line, SMMC-7721, was also shown to increase sensitivity to chemotherapeutics such as fluorouracil, mitomycin, and cisplatin [104].