AVP and ductal breast carcinoma in situ: As the whole-gene expression profile of patient-matched atypical ductal hyperplasia (ADH) was also available, we further compared DCIS and ADH profiles to verify the hypothesis according to which breast cancer progression is a multistep process involving a continuum of changes from normal phenotype through hyperplastic lesions, carcinoma in situ, and invasive carcinoma [21].