Similarly, another study performed in silico investigation on 18 missense mutations in electron transfer flavoprotein (ETF) associated with multiple acyl-coa dehydrogenase deficiency (MADD), and it was found that these 18 missense mutations can be classified into two groups by their molecular effects: altering protein folding and assembling, affecting the catalytic activity of functional sites, and disrupting interactions with their biological partner, that is, dehydrogenases in this case [106]. Here, TEAD2 is linked to multiple acyl-CoA dehydrogenase deficiency.