It was not found any difference between the groups regarding CI and SvO2 (mixed venous oxygen saturation) as well as in the enzymatic variables CPK-MB and troponin I.12 The Insulin Cardioplegia Trial13 evaluated the use of 10-IU insulin-fortified cardioplegia vs. placebo in high-risk patients undergone myocardial revascularization surgery due to unstable angina. The gene discussed is INS; the disease is angina pectoris.