Although in vasomotor rhinitis both TLR4 and TLR9 appeared to be significantly down-regulated, their co-localization in the cell infiltrate similar to that observed—but in a definitely higher degree—in rhinosinusitis may indicate that a neurogenic minimal inflammation does also occur in this “noninflammatory” rhinitis phenotype [27]. This evidence concerns the gene TLR9 and vasomotor rhinitis.