Circulating levels of some endothelial-derived factors, soluble cell adhesion molecules, von Willebrand factor (vWF), tissue plasminogen activator (t-PA), and plasminogen activator inhibitor type1 (PAI-1) have been linked to the risk of type 2 diabetes in populations without pGDM [8, 11–13]. This evidence concerns the gene VWF and type 2 diabetes mellitus.