PDGFRB and osteosarcoma: A Phase I study with Sunitinib, a multitargeted tyrosine kinase inhibitor of signaling downstream of VEGFR, PDGFR, FLT-3, B-Raf, and c-Kit, showed no objective responses in bone sarcomas except one “stable disease” response out of 2 patients with osteosarcoma [43] (Table 1).