Girdin binds to the actin cytoskeleton as well as many components of intracellular signaling pathways including the serine/threonine kinase Akt/PKB [6], [15], the trimeric G proteins Gαi/s that mediate signaling evoked by G protein–coupled receptors (GPCRs) [16]–[20], epidermal growth factor receptor (EGFR) [21], and DISC1 (Disrupted-In-Schizophrenia 1), a candidate gene for the development of schizophrenia and major mental disorders [8]. Here, DISC1 is linked to schizophrenia.