Girders of actin filaments (Girdin), also termed Gα-interacting vesicle associated protein (GIV) is an interesting actin-binding protein [6] which is expressed in limited types of cells including immature endothelial cells [7], immature neuroblasts [8], [9], smooth muscle cells [10], breast and colon cancer cells [11]–[13], and glioblastoma cells [14]. The gene discussed is CCDC88A; the disease is colonic neoplasm.