We and others previously showed that RNA interference (RNAi)-mediated depletion (knock-down) or targeted deletion of Girdin resulted in defective cell migration of immortalized fibroblasts, endothelial cells, smooth muscle cells, neuroblasts, and breast cancer cells [6], [7], [9], [10], [11], [14], [17], [19]. Here, CCDC88A is linked to breast carcinoma.