In the patients fulfilling only the 2010 ACR/EULAR criteria for RA there was interindividual variability, but on average the synovium was characterized by marked infiltration with macrophages, T cells, plasma cells, B cells and mast cells, increased numbers of synovial fibroblasts, hypervascularity, and overexpression of VCAM-1 and VEGF (See Figure 2). This evidence concerns the gene VEGFA and rheumatoid arthritis.