When present in homozygosity or in compound heterozygosity with another truncating mutation of GJB2 (referred as “the exclusive p.V37I genotype” because only the p.V37I allele(s) have the potential to produce protein product), it can lead to non-fully penetrant, mild-to-moderate hearing impairment that is sometimes progressive [17], [18]. This evidence concerns the gene GJB2 and hearing loss disorder.