WWOX and neoplasm: Upon breeding these mice with EIIA-Cre transgenic mice, we generated full Wwox KO mice and observed that these mice displayed severe metabolic defects, growth retardation and all mice died by 3 weeks of age as previously observed [19], however in contrast with the findings of Aqeilan and coworkers no evidence of spontaneous neoplasia was detected in these short-lived Wwox KO mice [19].