CD14 and infection: However, while Hla-dependent PMN plasma membrane permeability was not detected during USA300 infection and only minimally detected following intoxication with rHla, Hla significantly influenced CD14+ PBMC plasma membrane integrity at 6 hours post-infection with USA300 and rHla alone increased CD14+ PBMC plasma membrane permeability in a concentration dependent manner following 60 minutes intoxication.