TP63 and exstrophy-epispadias complex: Table S2 also listed several alterations related to oral-craniofacial development, including micrognathia (1/9), bilateral cleft lip-palate (1/9), malformed teeth (3/8), and hypodontia (4/8) (Figure 2). Taken together, typical EEC phenotypes were observed in patient IV-3, EE phenotypes in II-9, III-3, III-5, and IV-2, possible isolated SHFM4 phenotypes in I-2, III-7, and IV-4, and isolated Ectodermal dysplasia in II-3 (Table S2).