Review of the previously reported EEC patients [13]–[17] and SHFM4 patients with six different DBD mutations [2], [13], [18], including K193E [19], K194E [7], [19], [20], R280C, R280H (but not R280/S that causes EEC) [7], [19], [21], [22], G310E [23], the proline insertion between T154–Y155 [19], and patients in this study, revealed a wide phenotypic spectrum of the TP63 gene mutations. Here, TP63 is linked to exstrophy-epispadias complex.