The DBD is present in all splicing isoforms of p63, but its mutations result in multiple syndromes, such as the most prevalent ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC), the ectrodactyly-ectodermal dysplasia syndrome (EE), the isolated Ectodermal dysplasia, and the isolated split hand/foot malformation type 4 (SHFM4) [2], [7]. This evidence concerns the gene TP63 and ectodermal dysplasia syndrome.