Several studies have shown that long term Ang II infusion (over 4 weeks,) caused cardiac hypertrophy, remodeling and cardiac dysfunction in mice [30], [31], however, short term infusion of Ang II infusion (7 days) was not enough to cause cardiomyocyte hypertrophy thus cardiac dysfunction, but instead, caused cardiac inflammation. The gene discussed is AGT; the disease is cardiac hypertrophy.