MAPK8 and cancer: Although not in leukocytes, an influence of flavopiridol on the activation of these dominant pro-inflammatory signal transducers has been confirmed by Takada et al. [81], who demonstrated that flavopiridol inhibits the activation of JNK/AP-1, p38 MAPK, JNK, and ERK, as well as the expression of ICAM-1 upon TNFα treatment in different cancer cell lines.