A complementary perspective on the dynamic dialogue between the stroma and the tumor cells, which impacts metastasis of tumor cells to bone, is provided by E. Bevilacqua et al. in “RKIP suppresses breast cancer metastasis to the bone by regulating stroma-associated genes.” This focuses on the metastasis suppressor, Raf Kinase Inhibitory Protein (RKIP), and its ability to influence the tumor microenvironment in the bone. The gene discussed is PEBP1; the disease is breast carcinoma.