PON3 and cardiovascular disorder: In contrast to PON2, which is ubiquitously expressed, PON3 appears restricted to fewer tissues/cells; its expression in cells relevant to cardiovascular diseases is contradictory, because Marsillach et al. [15] found PON3 by immunohistochemistry in human vascular walls and macrophages, while our studies revealed absence in macrophages, endothelial, smooth muscle, and many other cell types [16].