Several recurrent genetic aberrations, such as trisomy of chromosome 12, deletions in 7q, and mutation affecting the mediator complex subunit 12 (MED12) or the high mobility group AT-hook 2 (HMGA2) gene were reported in uterine leiomyomas [15], [16], [17], [18]. This evidence concerns the gene MED12 and uterine corpus leiomyoma.