Similarly, the safety data of rituximab plus EPOCH reported in patients with HIV-DLBCL [20], and implicit in the 100% survival preliminarily reported for those with HIV-BL [22], indicates that rituximab can be safely given to patients with ARL, particularly to those in whom baseline CD4 count is greater than 50/μL. In the HIV-negative population, the addition of rituximab appears to improve outcomes in BL when added to intensive multiagent chemotherapy [30]. The gene discussed is CD4; the disease is Burkitt lymphoma.