Addition of 3-Cl-AHPC downregulated β-catenin expression in pancreatic cancer cells and inhibited Wnt/β-catenin activation of transcription factor TCF/LEF and also downregulated Wnt/β-catenin pathway responsive genes cyclin D1 and c-Myc in PANC-1 cells. The gene discussed is HNF4A; the disease is familial pancreatic carcinoma.