We have found that both 3-Cl-AHPC and AHP3 significantly decreased IGF-1R and β-catenin expression and that the decreased expression of IGF-1R and β-catenin inhibited the growth and enhanced apoptosis of the pancreatic cancer cells suggesting that decreased IGF-1R and β-catenin expression potentiates ARR-mediated apoptosis. This evidence concerns the gene IGF1R and pancreatic neoplasm.