In MALME-3M (high endogenous M-MITF level) and UACC62 cells (low endogenous M-MITF level), overexpression of M-MITF by adenovirus infection was sufficient to induce the transcription of multiple melanocyte differentiation genes (Figure 4D and 4E, Figure S4). This evidence concerns the gene MITF and adenoviridae infectious disease.