LRP1 is decreased in the optic neuropathy associated with Alzheimer's disease [45], LRP1B is associated with optic nerve area [22], a knock-out of LRP2 causes a glaucoma-like phenotype in zebrafish [46], LRP4 expression is increased in response to retinal ischemia [47], and expression of LRP10 and LRP11 is up-regulated in a rat model of glaucoma [48], [49]. Here, LRP2 is linked to early-onset autosomal dominant Alzheimer disease.