SIX6 and open-angle glaucoma: Using METAL [18], we conducted a meta-analysis of the GLAUGEN and NEIGHBOR datasets that included a total of 3,146 cases and 3,487 controls and found nineteen SNPs that achieved genome-wide significance for POAG overall (Figure S5): seventeen of them in the CDKN2BAS region, with the most significant SNP being rs2157719 (OR = 0.69 [95%CI 0.63–0.75], p = 1.86×10−18, and two SNPs in the SIX1/SIX6 region on chromosome 14q23 (most significant SNP: rs10483727, OR = 1.32 [95%CI 1.21–1.43], p = 3.87×10−11) (Table S3).