CDKN2B-AS1 and open-angle glaucoma: The first region includes the CDKN2BAS gene on chromosome 9p21, previously associated with cup-to-disc ratio (CDR) an optic nerve quantitative parameter, as well as POAG in candidate gene studies [20], [35], [36] and more recently in a GWAS using a sample of severely affected POAG patients [12].