Recent genome-wide association studies (GWAS) have identified several genetic risk factors for POAG overall, including single-nucleotide polymorphisms (SNPs) located in the CAV1/CAV2 intergenic region [10]–[11], and in the genomic regions containing the TMCO1 and CDKN2BAS genes [12] in a study of glaucoma patients with advanced optic nerve disease. This evidence concerns the gene CDKN2B-AS1 and open-angle glaucoma.