Consistent with a Tlr3/Trif-mediated stimulation of adult IECs after rotavirus infection, epithelial expression of Ifn-λ and the chemokine Rantes was significantly enhanced at day 4 p.i. in wild-type mice, whereas no or only weak induction was observed in IECs isolated from TrifLps2/Lps2 (Figure 5A and B, left panel) or Tlr3−/− mice (Figure 5A and B, right panel). The gene discussed is TICAM1; the disease is Rotavirus infection.