Simulations that exhibit ET1 CNV and later invade the sub-retinal space in P13 CNV (Table 7, RRl = 1, independent of RRp, RBl = 1, RBp = 1 or 2, ROl = 3) correspond to the most common clinically observed progression of AMD-induced CNV, which begins as sub-RPE CNV and later progresses to involve the sub-retinal space. The gene discussed is EDN1; the disease is age-related macular degeneration.