IFNB1 and relapsing-remitting multiple sclerosis: Several clinical studies of different statins in different dosages given alone or in combination with interferon beta (IFNB) for relapsing-remitting MS (RRMS) yielded beneficial, harmful, or no effects as summarized in Table 1, whereas the largest trial of simvastatin as add-on therapy to interferon beta-1a (SIMCOMBIN) showed no beneficial effect [9–15].